Valeta Young， 81， a retiree from Lodi， Calif.， suffers from congestive heart failure and requires almost constant monitoring. But she doesn't have to drive anywhere to get it. Twice a day she steps onto a special electronic scale， answers a few yes or no questions via push buttons on a small attached monitor and presses a button that sends the information to a nurse's station in San Antonio， Texas. “It's almost a direct link to my doctor，” says Young， who describes herself as computer illiterate but says she has no problems using the equipment.
Young is not the only patient who is dealing with her doctor from a distance. Remote monitoring is a rapidly growing field in medical technology， with more than 25 firms competing to measure remotely——and transmit by phone， Internet or through the airwaves——everything from patients' heart rates to how often they cough.
Prompted both by the rise in health-care costs and the increasing computerization of health-care equipment， doctors are using remote monitoring to track a widening variety of chronic diseases. In March， St. Francis University in Pittsburgh， Pa.， partnered with a company called BodyMedia on a study in which rural diabetes patients use wireless glucose meters and armband sensors to monitor their disease. And last fall， Yahoo began offering subscribers the ability to chart their asthma conditions online， using a PDA-size respiratory monitor that measures lung functions in real time and e-mails the data directly to doctors.
Such home monitoring， says Dr. George Dailey， a physician at the Scripps Clinic in San Diego， “could someday replace less productive ways that patients track changes in their heart rate， blood sugar， lipid levels， kidney functions and even vision.”
Dr. Timothy Moore， executive vice president of Alere Medical， which produces the smart scales that Young and more than 10，000 other patients are using， says that almost any vital sign could， in theory， be monitored from home. But， he warns， that might not always make good medical sense. He advises against performing electrocardiograms remotely， for example， and although he acknowledges that remote monitoring of blood-sugar levels and diabetic ulcers on the skin may have real value， he points out that there are no truly independent studies that establish the value of home testing for diabetes or asthma.
Such studies are needed because the technology is still in its infancy and medical experts are divided about its value. But on one thing they all agree： you should never rely on any remote testing system without clearing it with your doctor.
注(1)：本文选自Time;8/9/2004， p101-101， 1/2p， 2c;
注(2)：本文习题命题模仿对象2004年真题text 1;
1. How does Young monitor her health conditions?
[A] By stepping on an electronic scale.
[B] By answering a few yes or no questions.
[C] By using remote monitoring service.
[D] By establishing a direct link to her doctor.
2. Which of the following is not used in remote monitoring?
[A] car
[B] telephone
[C] Internet
[D] the airwaves
3. The word “prompted” (Line 1， Paragraph 3) most probably means ________.
[A] made
[B] reminded
[C] aroused
[D] driven
4. Why is Dr. Timothy Moore against performing electrocardiograms remotely?
[A] Because it is a less productive way of monitoring.
[B] Because it doesn‘t make good medical sense.
[C] Because it‘s value has not been proved by scientific study
[D] Because it is not allowed by doctors
5. Which of the following is true according to the text?
[A] Computer illiterate is advised not to use remote monitoring.
[B] The development of remote monitoring market is rather sluggish.
[C] Remote monitoring is mainly used to track chronic diseases.
[D] Medical experts agree on the value of remote monitoring.
答案：CADBCDr. Wise Young has never met the hundreds of thousands of people he has helped in the past 10 years， and most of them have never heard of Wise Young. If they did meet him， however， they'd want to shake his hand——and the remarkable thing about that would be the simple fact that so many of them could. All the people Young has helped were victims of spinal injuries， and they owe much of the mobility they have today to his landmark work.
Young， 51， head of the W.M. Keck Center for Collaborative Neuroscience at Rutgers University in New Brunswick， N.J.， was born on New Year's Day at the precise midpoint of the 20th century. Back then， the thinking about spinal-cord injury was straightforward： When a cord is damaged， it's damaged. There's nothing that can be done after an injury to restore the function that was so suddenly lost. As a medical student at Stanford University and a neurosurgeon at New York University Medical Center， Young never had much reason to question that received wisdom， but in 1980 he began to have his doubts. Spinal cords， he knew， experience progressive damage after they're injured， including swelling and inflammation， which may worsen the condition of the already damaged tissue. If that secondary insult could be relieved with drugs， might some function be preserved?
Young spent a decade looking into the question， and in 1990 he co-led a landmark study showing that when high doses of a steroid known as methylprednisolone are administered within eight hours of an injury， about 20% of function can be saved. Twenty percent is hardly everything， but it can often be the difference between breathing unassisted or relying on a respirator， walking or spending one's life in a wheelchair. “This discovery led to a revolution in neuroprotective therapy，” Young says.
A global revolution， actually. More than 50，000 people around the world suffer spinal injuries each year， and these days， methylprednisolone is the standard treatment in the U.S. and many other countries. But Young is still not satisfied. The drug is an elixir for people who are newly injured， but the relief it offers is only partial， and many spinal-injury victims were hurt before it became available. Young's dream is to help those people too——to restore function already lost——and to that end he is studying drugs and growth factors that could improve conduction in damaged nerves or even prod the development of new ones. To ensure that all the neural researchers around the world pull together， he has created the International Neurotrauma Society， founded the Journal of Neural Trauma and established a website (carecure.rutgers.edu) that receives thousands of hits each day.
“The cure for spinal injury is going to be a combination of therapies，” Young says. “It's the most collaborative field I know.” Perhaps. But increasingly it seems that if the collaborators had a field general， his name would be Wise Young.
注(1)：本文选自Time;8/20/2001， p54;
注(2)：本文习题命题模仿对象2004年真题text 3;
1. By “the remarkable thing about that would be the simple fact that so many of them could”(Line three， Paragraph 1)， the author means_______________.
[A] The remarkable thing is actually the simple fact.
[B] Many people could do the remarkable things.
[C] When meeting him， many people could do the simple but remarkable thing.
[D] The remarkable thing lies in the simple fact that so many people could shake hands with him.
2. How did people think of the spinal-cord injury at the middle of 20th century?
[A] pessimistic
[B] optimistic
[C] confused
[D] carefree
3. By saying “Twenty percent is hardly everything”(Line 3， Paragraph 3)， the author is talking about_____________.
[A] the drug
[B] the function of the injured body
[C] the function of the drug
[D] the injury
4. Why was Young unsatisfied with his achievement?
[A] The drug cannot help the people who had spinal injury in the past.
[B] His treatment is standard.
[C] The drug only offers help to a small number of people.
[D] The drug only treats some parts of the injury.
5. To which of the following statements is the author likely to agree?
[A] Wise Young does not meet many people.
[B] When Young was young， he did not have much reason to ask questions.
[C] If there needs a head of the spinal-injured field， Young might be the right person.
[D] Young‘s dream is only to help the persons who were injured at early times.
答案：D A B A C Scientists have known for more than two decades that cancer is a disease of the genes. Something scrambles the Dna inside a nucleus， and suddenly， instead of dividing in a measured fashion， a cell begins to copy itself furiously. Unlike an ordinary cell， it never stops. But describing the process isn't the same as figuring it out. Cancer cells are so radically different from normal ones that it's almost impossible to untangle the sequence of events that made them that way. So for years researchers have been attacking the problem by taking normal cells and trying to determine what changes will turn them cancerous——always without success.
Until now. According to a report in the current issue of Nature， a team of scientists based at M.I.T.'s Whitehead Institute for Biomedical Research has finally managed to make human cells malignant——a feat they accomplished with two different cell types by inserting just three altered genes into their DNA. While these manipulations were done only in lab dishes and won't lead to any immediate treatment， they appear to be a crucial step in understanding the disease. This is a “landmark paper，” wrote Jonathan Weitzman and Moshe Yaniv of the Pasteur Institute in Paris， in an accompanying commentary.
The dramatic new result traces back to a breakthrough in 1983， when the Whitehead's Robert Weinberg and colleagues showed that mouse cells would become cancerous when spiked with two altered genes. But when they tried such alterations on human cells， they didn't work. Since then， scientists have learned that mouse cells differ from human cells in an important respect： they have higher levels of an enzyme called telomerase. That enzyme keeps caplike structures called telomeres on the ends of chromosomes from getting shorter with each round of cell division. Such shortening is part of a cell's aging process， and since cancer cells keep dividing forever， the Whitehead group reasoned that making human cells more mouselike might also make them cancerous.
The strategy worked. The scientists took connective-tissue and kidney cells and introduced three mutated genes——one that makes cells divide rapidly; another that disables two substances meant to rein in excessive division; and a third that promotes the production of telomerase， which made the cells essentially immortal. They'd created a tumor in a test tube. “Some people believed that telomerase wasn't that important，” says the Whitehead's William Hahn， the study's lead author. “This allows us to say with some certainty that it is.”
Understanding cancer cells in the lab isn't the same as understanding how it behaves in a living body， of course. But by teasing out the key differences between normal and malignant cells， doctors may someday be able to design tests to pick up cancer in its earliest stages. The finding could also lead to drugs tailored to attack specific types of cancer， thereby lessening our dependence on tissue-destroying chemotherapy and radiation. Beyond that， the Whitehead research suggests that this stubbornly complex disease may have a simple origin， and the identification of that origin may turn out to be the most important step of all.
注(1)：本文选自Time; 08/09/99， p60， 3/5p， 2c
注(2)：本文习题命题模仿对象2002年真题text 4
1. From the first paragraph， we learn that ________________.
[A] scientists had understood what happened to normal cells that made them behave strangely
[B] when a cell begins to copy itself without stopping， it becomes cancerous
[C] normal cells do no copy themselves
[D] the DNA inside a nucleus divides regularly
2. Which of the following statements is true according to the text?
[A] The scientists traced the source of cancers by figuring out their DNA order.
[B] A treatment to cancers will be available within a year or two.
[C] The finding paves way for tackling cancer.
[D] The scientists successfully turned cancerous cells into healthy cells.
3. According to the author， one of the problems in previous cancer research is ________.
[A] enzyme kept telomeres from getting shorter
[B] scientists didn‘t know there existed different levels of telomerase between mouse cells and human cells
[C] scientists failed to understand the connection between a cell‘s aging process and cell division.
[D] human cells are mouselike
4. Which of the following best defines the word “tailored” (Line 4， Paragraph 5)?
[A] made specifically
[B] used mainly
[C] targeted
[D] aimed
5. The Whitehead research will probably result in ___________.
[A] a thorough understanding of the disease
[B] beating out cancers
[C] solving the cancer mystery
[D] drugs that leave patients less painful
答案：B C B A DWhen Ellen M. Roche， 24， volunteered for the asthma experiment， she didn't expect to benefit from it——except for the $365 she'd be paid. Unlike clinical trials， in which most patients hope that an experimental therapy will help them， this study was designed just to answer a basic question： how does the way a normal lung reacts to irritants shed light on how an asthmatic lung responds? To find out， scientists led by Dr. Alkis Togias of Johns Hopkins University had Roche and other healthy volunteers inhale a drug called hexamethonium. Almost immediately Roche began to cough and feel short of breath. Within weeks her lungs failed and her kidneys shut down. On June 2 Roche died——a death made more tragic by the possibility that it was preventable. Last week the federal Office for Human Research Protections (OHRP) ruled that Hopkins's system for protecting human subjects is so flawed that virtually all its U.S.-supported research had to stop.
The worst part is that Hopkins， one of the nation's premier medical institutions， is not alone. Two years ago the inspector general of the Department of Health and Human Services warned that the system safeguarding human subjects is in danger of a meltdown. The boards that review proposed studies are overburdened， understaffed and shot through with conflicts of interest. Oversight is so porous that no one knows how many people volunteer to be human guinea pigs (21 million a year is an educated guess)， how many are hurt or how many die. “Thousands of deaths are never reported， and adverse events in the tens of thousands are not reported，” says Adil Shamoo， a member of the National Human Research Protections Advisory Committee and professor at the University of Maryland. Greg Koski， head of OHRP， has called the clinical-trials system “dysfunctional.”
The OHRP findings on Hopkins are nothing short of devastating. After a three-day inspection last week， OHRP concluded that the Hopkins scientists failed to get information on the link between hexamethonium and lung toxicity， even though data were available via “routine” Internet searches and in textbooks. The drug is not approved for use in humans; the hexa-methonium Togias used was labeled [F]OR LABORATORY USE ONLY. The review board， OHRP charges， never asked for data on the safety of inhaled hexamethonium in people. The consent form that Roche signed states nowhere that hexamethonium is not approved by the FDA (the form describes it as a “medication”) and didn't warn about possible lung toxicity.
Hopkins itself concluded that the review board did not do all it could to protect the volunteers， and suspended all 10 of Togias's studies. Still， the university——whose $301 million in federal grants for 2，000 human studies made it the largest recipient of government research money last year——is seething. “Hopkins has had over 100 years of doing clinical trials，” says Dr. Edward Miller， CEO of Johns Hopkins Medicine. “We have had one death in all of those years. We would have done anything in the world to prevent that death， but [suspending the studies] seems out of proportion.” Hopkins calls the shutdown of its experiments “unwarranted， unnecessary， paralyzing and precipitous.” OHRP is letting trials continue “where it is in the best interests” of subjects. The rest of the studies can resume once Hopkins submits a plan to restructure its system for protecting research subjects. How quickly that happens， says a government spokesman， depends on Hopkins.
注(1)：本文选自Newsweek; 7/30/2001， p36;
注(2)：本文习题命题模仿对象2005年真题Text 1;
1. In the opening paragraph， the author introduces his topic by
[A]explaining a phenomenon
[B]justifying an assumption
[C]stating an incident
[D]making a comparison
2. The statement “The OHRP findings on Hopkins are nothing short of devastating.”(Line
1， Paragraph 3) implies that
[A]The OHRP findings on Hopkins are much too impressive.
[B]The OHRP findings on Hopkins are much too shocking.
[C]The OHRP findings on Hopkins are much too convincing.
[D]The OHRP findings on Hopkins are much too striking.
3. The main reasons for Roche‘s death are as following， except that _______.
[A]the protecting system hasn‘t been set up
[B]the review board has neglected their duty
[C]the research team was not responsible enough for its volunteers
[D]the possibility of lung toxicity was overlooked
4. The OHRP has found that
[A]Hopkins has loose control over the experiment.
[B]the volunteers knew nothing about the experiment.
[C]there is something wrong with every aspect of the experiment.
[D]there exist many hidden troubles in human subjects safeguarding system.
5. What can we infer from the last paragraph?
[A]Hopkins had no fault in this accident.
[B]Hopkins seemed not to quite agree with The OHRP
[C]Togias's studies shouldn‘t be suspended.
[D]Hopkins wanted to begin their experiments as soon as possible.
答案：CBACBYou hop into your car， but， wait， where are the keys? You meet someone new， but her name is gone before the handshake's over. Those are failures of your short-term， or “working，” memory——the place you file information for immediate， everyday retrieval. It isn't perfect. But researchers are increasingly convinced that the hormone estrogen could play a key role in maintaining and perhaps even improving memory. Last week a team of Yale scientists provided dramatic new evidence that bolsters the theory. Using MRIs——detailed snapshots of the brain——researchers found that women taking estrogen show significantly more activity in brain areas associated with memory than women on a placebo. “This is very exciting，” says Yale's Dr. Sally Shaywitz. “It means that the brain circuitry for memory had altered.”
After menopause， when estrogen levels plummet， some women become forgetful. Past research has demonstrated that those who take estrogen do better on memory tests than their nonmedicated peers do. The hormone may even reduce the risk of Alzheimer's. The new study， published in last week's Journal of the American Medical Association， is the first to visually compare the neurocircuitry of memory both on and off estrogen. The drug made a big difference to participant Bernadette Settelmeyer： “All of a sudden I was remembering things.”
The women (whose average age was 51) lay down in a brain-imaging machine where they were shown two types of information： nonsense words (“BAZ” or “DOB”) to test verbal memory and geometric patterns to assess visual memory. After a 20-second “storage” period， participants saw a mix of old and new and were asked if anything looked familiar. During each stage of the test——as the women encoded， stored and retrieved data——researchers took pictures of their brains. The 46 women underwent the test twice——once while taking a standard daily dose of estrogen and again while taking a placebo. Beyond the power of estrogen， the difference in MRIs suggests that the adult brain maintains “plasticity”——the ability to rewire itself——even as it ages.
There is still plenty of research to be done. Scientists can't yet be sure estrogen is directly responsible for better memory performance. Despite the difference in brain activity on and off estrogen， participants' scores did not change. Researchers say that is probably because the tasks were so simple (the women got more than 90 percent correct overall)。 Other studies on estrogen and cognition are short term——and their findings have been inconsistent. And scientists still can't answer the question facing millions of women： should I take hormone-replacement therapy? The new study may make estrogen more appealing， but it should be just “one part of the equation，” says Shaywitz. Still， it's a memorable one.
注(1)：本文选自Newsweek; 04/19/99， p50;
注(2)：本文习题命题模仿对象2002年真题Text 3;
1. The following are the examples of the failures of short-term memory， except that ___________.
[A]you are not sure whether you‘ve locked the door or not
[B]you cannot recall all your previous experience
[C]you cannot find the key to your car when starting it
[D]you forget the name of a stranger before the greeting is over
2. It can be inferred from the text that women‘s working memory could probably be improved if _________.
[A]they overuse estrogen
[B]they participate in the experiment
[C]their minds are kept active
[D]the estrogen level is raised
3. The experiment involving 46 ladies shows that _______.
[A]the women should take a normal dose of estrogen
[B]the women‘s brains still have the ability of creation
[C]the estrogen level determines their memory bad or good
[D]the estrogen makes the brain work more actively
4. We can draw a conclusion from the text that ________.
[A]the connection between estrogen and memory is still an open study
[B]the hormone estrogen plays a key role in improving memory.
[C]the low level estrogen makes a woman forgetful
[D]raising the estrogen level can improve the women‘s short-term memory
5. From the text we can see the writer seems ________.
[A]objective
[B]optimistic
[C]sensitive
[D]gloomy
答案：BDDAAAt 18， Ashanthi DeSilva of suburban Cleveland is a living symbol of one of the great intellectual achievements of the 20th century. Born with an extremely rare and usually fatal disorder that left her without a functioning immune system (the “bubble-boy disease，” named after an earlier victim who was kept alive for years in a sterile plastic tent)， she was treated beginning in 1990 with a revolutionary new therapy that sought to correct the defect at its very source， in the genes of her white blood cells. It worked. Although her last gene-therapy treatment was in 1992， she is completely healthy with normal immune function， according to one of the doctors who treated her， W. French Anderson of the University of Southern California. Researchers have long dreamed of treating diseases from hemophilia to cancer by replacing mutant genes with normal ones. And the dreaming may continue for decades more. “There will be a gene-based treatment for essentially every disease，” Anderson says， “within 50 years.”
It's not entirely clear why medicine has been so slow to build on Anderson's early success. The National Institutes of Health budget office estimates it will spend $432 million on gene-therapy research in 2005， and there is no shortage of promising leads. The therapeutic genes are usually delivered through viruses that don't cause human disease. “The virus is sort of like a Trojan horse，” says Ronald Crystal of New York Presbyterian/Weill Cornell Medical College. “The cargo is the gene.”
At the University of Pennsylvania's Abramson Cancer Center， immunologist Carl June recently treated HIV patients with a gene intended to help their cells resist the infection. At Cornell University， researchers are pursuing gene-based therapies for Parkinson's disease and a rare hereditary disorder that destroys children's brain cells. At Stanford University and the Children's Hospital of Philadelphia， researchers are trying to figure out how to help patients with hemophilia who today must inject themselves with expensive clotting drugs for life. Animal experiments have shown great promise.
But somehow， things get lost in the translation from laboratory to patient. In human trials of the hemophilia treatment， patients show a response at first， but it fades over time. And the field has still not recovered from the setback it suffered in 1999， when Jesse Gelsinger， an 18-year-old with a rare metabolic disorder， died after receiving an experimental gene therapy at the University of Pennsylvania. Some experts worry that the field will be tarnished further if the next people to benefit are not patients but athletes seeking an edge. This summer， researchers at the Salk Institute in San Diego said they had created a “marathon mouse” by implanting a gene that enhances running ability; already， officials at the World Anti-Doping Agency are preparing to test athletes for signs of “gene doping.” But the principle is the same， whether you're trying to help a healthy runner run faster or allow a muscular-dystrophy patient to walk. “Everybody recognizes that gene therapy is a very good idea，” says Crystal. “And eventually it's going to work.”
注(1)：本文选自Newsweek;12/6/2004， p55-55， 2/3p， 1c;
注(2)：本文习题命题模仿对象： 第1、2题分别模仿2003年真题text1的第2题和第1题;第3、4题分别模仿2004年真题text1的第5 题和第3题;第5题模仿2002年真题text3的第5题;
1. The case of Ashanthi Desilva is mentioned in the text to ____________.
[A] show the promise of gene-therapy
[B] give an example of modern treatment for fatal diseases
[C] introduce the achievement of Anderson and his team
[D] explain how gene-based treatment works
2. Anderson‘s early success has ________________.
[A] greatly speeded the development of medicine
[B] brought no immediate progress in the research of gene-therapy
[C] promised a cure to every disease
[D] made him a national hero
3. Which of the following is true according to the text?
[A] Ashanthi needs to receive gene-therapy treatment constantly.
[B] Despite the huge funding， gene researches have shown few promises.
[C] Therapeutic genes are carried by harmless viruses.
[D] Gene-doping is encouraged by world agencies to help athletes get better scores.
4. The word “tarnish” (line 5， paragraph 4) most probably means ____________.
[A] affect
[B] warn
[C] trouble
[D] stain
5. From the text we can see that the author seems ___________.
[A] optimistic
[B] pessimistic
[C] troubled
[D] uncertain
答案：A B C D AShortages of flu vaccine are nothing new in America， but this year's is a whopper. Until last week， it appeared that 100 million Americans would have access to flu shots this fall. Then British authorities， concerned about quality-control problems at a production plant in Liverpool， barred all further shipments by the Chiron Corp. Overnight， the U.S. vaccine supply dwindled by nearly half——and federal health officials found themselves making an unusual plea. Instead of beseeching us all to get vaccinated， they're now urging most healthy people between the ages of 2 and 64 not to. “This re-emphasizes the fragility of our vaccine supply，” says Dr. Martin Myers of the National Network for Immunization Information， “and the lack of redundancy in our system.”
Why is such a basic health service so easily knocked out? Mainly because private companies have had little incentive to pursue it. To create a single dose of flu vaccine， a manufacturer has to grow live virus in a 2-week-old fertilized chicken egg， then crack the egg， harvest the virus and extract the proteins used to provoke an immune response. Profit margins are narrow， demand is fickle and， because each year's flu virus is different， any leftover vaccine goes to waste. As a result， the United States now has only two major suppliers (Chiron and Aventis Pasteur)——and when one of them runs into trouble， there isn't much the other can do about it. “A vaccine maker can't just call up and order 40 million more fertilized eggs，” says Manon Cox， of Connecticut-based Protein Sciences Corp. “There's a whole industry that's scheduled to produce a certain number of eggs at a certain time.”
Sleeker technologies are now in the works， and experts are hoping that this year's fiasco will speed the pace of innovation. The main challenge is to shift production from eggs into cell cultures——a medium already used to make most other vaccines. Flu vaccines are harder than most to produce this way， but several biotech companies are now pursuing this strategy， and one culture-based product (Solvay Pharmaceuticals' Invivac) has been cleared for marketing in Europe.
For America， the immediate challenge is to make the most of a limited supply. The government estimates that 95 million people still qualify for shots under the voluntary restrictions announced last week. That's nearly twice the number of doses that clinics will have on hand， but only 60 million Americans seek out shots in a normal year. In fact， many experts are hoping the shortage will serve as an awareness campaign——encouraging the people who really need a flu shot to get one.
注(1)：本文选自Newsweek; 10/18/2004， p57-57， 2/3p， 1c;
注(2)：本文习题命题模仿对象1—4题模仿1997年真题text 3，第5题模仿1997年真题text 4的第四小题;
1. Shortages of flue vaccine show that ____.
[A] America relies too much on foreign suppliers
[B] the demand of flue vaccines is high this year
[C] quality problem is a serious problem in flu vaccine production
[D] the supply of flu vaccines is rather weak and America has no back-up measures to make it up
2. The word “cleared” (Line 5， Paragraph 3) might mean ____.
[A]permitted
[B]removed
[C]proved
[D]produced
3. Private companies have little interest in producing flu vaccines because of ____.
[A]complicated process， high cost， low profit and high risk
[B]shortages of fertilized chicken eggs
[C]difficulty in growing live virus
[D]fast changing of flu virus
4. From the last paragraph we can infer that ____.
[A] the government hopes to solve the problem by way of volunteer restrictions
[B] more than 47 million Americans who are qualified to get flu vaccine shots can not get them this year
[C] America has to deal with a limited supply of flu vaccines this year
[D] normally only a small percentage of American population gets flu vaccine shots each year
5. According to the passage， which of the following is TRUE?
[A] All Americans are persuaded not to get vaccinated this year.
[B] The big problem in innovating flu vaccine producing technique is how to grow virus in a new way.
[C] More flu vaccines can not be produced in a short time because private companies refuse to produce more.
[D] Flu vaccines are easier than most vaccines to produce through cell cultures.
答案：D A A B BIt was a big week for Alzheimer's disease， and not just because PBS aired The Forgetting， a first-rate documentary about Alzheimer's worth catching in reruns if you missed it the first time. There was also a flurry of scientific news that offered hope to the families already struggling with Alzheimer's， as well as to the baby-boom generation that's up next. Unless something dramatic happens， the number of Americans living with this terrifying brain disease could triple， to about 16 million， over the next 50 years. There's still no cure in sight， but there is progress on several fronts. Among them：
MEGADOSE VITAMINS Doctors knew vitamins E and C， both antioxidants， help stave off Alzheimer's， at least in folks who haven't already developed the disorder. What they didn't know——but a big study involving 4，740 participants published in the Archives of Neurology showed——was that the two vitamins taken together in huge daily doses (at least 400 IU of E and more than 500 mg of C) could reduce the risk of Alzheimer's a remarkable 78%.
COMBINATION THERAPY A yearlong study of more than 400 Alzheimer's patients showed that two drugs that work differently on the brain's chemistry act well together to help slow down the disease. Patients who were being treated with donepezil (sold as Aricept)， an older drug that preserves the neurotransmitter acetylcholine， were also given memantine (Namenda)， a new drug approved by the FDA last October that blocks overproduction of a harmful brain chemical called glutamate. The two drugs worked even better in combination than they did alone， providing substantial benefit for patients with moderate to severe Alzheimer's， according to a report in the Journal of the American Medical Association.
BRAIN IMAGING Finally， scientists at the University of Pittsburgh announced that they had successfully developed a procedure that allows them to peer into the brains of Alzheimer's patients with positron emission tomography (PET) scans to see telltale plaque deposits. Before now， doctors could not track the progress of these plaques until after the patient died， when the brain could be autopsied. Using the new technique， doctors may be able to begin treatment long before the first symptoms appear.
None of these advances is a magic bullet for Alzheimer's disease. If you or your loved ones are concerned， the first step is careful evaluation by your doctor. Not all memory lapses are Alzheimer's， and there are reversible causes of forgetfulness that can be treated if caught early. Also， remember the old adage “use it or lose it.” Mental exercise——reading， doing crossword puzzles， playing chess or Scrabble——is as good for preserving your mind as physical exercise is for your body.
注(1)：本文选自Time; 2/2/2004， p78-78， 2/3p， 2c;
注(2)：本文习题命题模仿对象第1题模仿2002年text 4第1题;第2题模仿1994年真题text 2 第3题;第3模仿2002年真题text 3 第3题，第4—5题模仿2004年text 3第4，5题;
1. From the first paragraph， we learn that_________.
[A] the baby-boom generation will not suffer from Alzhemer‘s disease
[B] recent progress brings hope for Alzheimer victims
[C] the week was very important for Alzheimer‘s because a documentary about it was shown on PBS
[D] the new achievements made on several fronts show that Alzheimer‘s disease can be cured
2. The phrase “stave off” (line 1， paragraph 2) most probably means “________”。
[A] getting
[B] treating
[C] curing
[D] preventing
3. The report in the Journal of the American Medical Association shows that ____________.
[A] combination therapy refers to combining two different ways of treatment
[B] donepezil helps blocks overproduction of a harmful brain chemical called glutamate
[C] combination therapy is of great benefit to all patients with Alzheimer‘s
[D] Aricept and Namenda have better effect when used together than used separately
4. Why is brain imaging considered progress in treating Alzhemer‘s?
[A] Because it helps doctors diagnose and treat the disease in an early phase by tracking the progress of plaques in the brain.
[B] Because it helps doctors autopsy the brains of the patients after they died.
[C] Because it helps doctors see the plaque desposits clearly so that they can operate on the brain.
[D] Because it helps doctors develop a new procedure of tracking the progress of the disease.
5. To which of the following is the author likely to agree?
[A] Alzhemer‘s disease can be cured thanks to the new advances.
[B] Forgetfulness can be cured by doing mental exercise.
[C] Careful evaluation is important because it can tell Alzheimer‘s from curable memory lapses， which can be treated if found in an early phase.
[D] Mental exercises do good only to forgetfulness caused by reversible causes.
答案：B D D A CThe countdown goes something like this： 3) IRS auditor， 2) ex-husband's new 20-year-old girlfriend， 1) dentist. The top three people we most hate to see.
“Let's face it，” says Dr. Lorin Berland， a dentist in Dallas. “Dentistry can suck.” A third of Americans， according to the National Center for Health Statistics， haven't even set foot in the dentist's office in the past year. Berland， along with an increasing number of dentists all over the country， is trying to change that. He wants dental appointments to be less about pain and drilling and more about relaxation， foot massage and soothing aromatherapy.
Spa dentistry， as it's called， means you can enjoy a hot paraffin-wax hand treatment while getting your teeth cleaned. Or you can slip on some virtual-reality glasses and watch your favorite movie. Or you might just lie back and let the scent of lavender and the sound of falling water quiet your anxiety， while a licensed massage therapist eases the crick in your neck. Most vacations aren't this good. In response to spa dentistry's growing popularity， the Chicago Dental Society will teach its first course on the practice at its annual midwinter meeting in February， expected to attract 35，000 industry professionals.
“Some people are born to cater to people， and others have to be taught，” says Dr. Grace Sun， a dentist in Los Angeles who， without benefit of a lecture， offers massage， fruit smoothies and movies. In addition， she provides luxury hotel-style concierge services： while you're in the (vibrating， of course) chair， her staff makes dinner reservations， takes your cell-phone calls， baby-sits， dog-sits， orders in food or does just about anything else you ask.
Dr. Debra Gray King of the Atlanta Center for Cosmetic Dentistry calls her practice “the Ritz-Carlton of dentistry” and in fact sends her “dental concierges” to the Ritz-Carlton Leadership Center for training in client relations. They're taught to squire each patient as he or she navigates the various rooms of the center's luxe 8，400-sq.-ft. Twelve Oaks——esque mansion. Once in the dentist's chair， King's patients can use the attached flat-panel monitor to watch TV， play a DVD or surf the Web. Can't see the screen? No worries， there's one wired to the ceiling too. Noise-reduction headphones block the screech of the drill and play a CD of your choice， and the specially constructed dental chair channels the sound waves from the music into a full-body massage. “The more relaxed the patient is，” says King， “the easier our job.”
Patients are responding. Martha Dickey， a magazine publisher in Atlanta， says a hot paraffin-wax treatment can “change your whole feeling about going to the dentist. You feel like you're there to get nurtured and pampered. It's fabulous. Every one of your senses is taken care of.” If only the offices of the IRS were as pleasant.
注(1)：本文选自Time; 12/30/2002-1/6/2003， p155， 3/4p， 1c;
注(2)：本文习题命题模仿对象2004年text 1;
1. How do Dr. Berland and some other American dentists try to change the image of
dentistry?
[A] They try to change it by facing it bravely.
[B] They try to change it by teaching patients how to take good care of their teeth.
[C] They try to change it by providing new services to help patients feel relaxed and at home.
[D] They try to change it by relieving patients‘ pain with new pills.
2. Which of the following is not a service provided by spa dentistry?
[A] a vacation
[B] spa
[C] massage
[D] dental treatment
3. The expression “cater to” (Line 1， Paragraph 4) most probably means _______.
[A] meet the requirements of sb.
[B] be to sb‘s liking
[C] take sb. seriously
[D] serve sb. well
4. Why does Dr. Debra Gray King call her practice “the Ritz-Carlton of dentistry”?
[A] Because her “dental concierges” are trained at the Ritz-Carlton Leadership Center.
[B] Because her cosmetic dentistry center provides the kind of concierge services luxury hotels like Ritz-Carlton provide.
[C] Because her Center is located in a mansion as large as Ritz-Carlton.
[D] Because her patients are also guests at Ritz-Carlton.
5. Which of the following is true according to the text?
[A] Dr. Grace Sun learned her new practice from the course offered by the Chicago Dental Society.
[B] The author hopes that dentist‘s offices can be as comfortable the offices of the IRS.
[C] The patients like the new services provided by the dentists mentioned in the text very much.
[D] Dental appointments are often associated with relaxation.
答案：C A D B CWHAT do you do when everyone hates you? That is the problem faced by America's pharmaceutical industry. Despite its successes in treating disease and extending longevity， soaring health-care costs and bumper profits mean that big drug firms are widely viewed as exploitative， and regarded almost as unfavourably as tobacco and oil firms (see chart)。 Last week， at a conference organised by The Economist in Philadelphia， the drug industry was offered some advice from an unlikely source： a tobacco firm. Steven Parrish of Altria， the conglomerate that includes Philip Morris， gave his perspective on how an industry can improve its tarnished public image.
Comparing the tobacco and pharmaceutical industries might seem absurd， or even offensive. “Their products kill people. Our products save people's lives，” says Alan Holmer， the head of the Pharmaceutical Research and Manufacturers of America， an industry association. Yet the drug giants currently face an unprecedented onslaught of class-action lawsuits and public scrutiny; industry bosses are being grilled by lawmakers asking who knew what and when. It is all reminiscent of what happened to the tobacco industry in 1994.
Mr Parrish advised drug firms to abandon their bunker mentality and engage with their critics. Rather than arguing about the past， he said， it is better to move on， and give people something new to think about. (Philip Morris now acknowledges， for example， that cigarettes are addictive and deadly， and is trying to develop less harmful products.) Not everyone is open to persuasion， so focus on those who are， he said. But changing opinions takes time and demands deeds as well as words： “This is not about spin， this is about change.”
The pharmaceutical industry is pursuing a range of initiatives to mollify its critics， Mr Holmer noted in his own speech. But Mr Parrish suggested that speaking with one voice through a trade association might be counter-productive， since it can give the impression that the industry is a monolithic cartel. And too much advertising， he said， can actually antagonise people further.
The audience was generally receptive， claims Mr Parrish. This is not the first time he has offered his thoughts on dealing with implacable critics. At a conference at the University of Michigan last year， he offered America's State Department advice on improving America's image in the Middle East. So does his prescription work? There has been a positive shift in attitudes towards tobacco firms， if only a small one. But at least， for once， a tobacco firm is peddling a cure， rather than a disease.
GRAPH： Unpopularity contest
Economist; 11/27/2004， Vol. 373 Issue 8403， p64-64， 1/3p， 1 graph
注(1)：本文选自Economist; 11/27/2004， p64-64， 1/3p， 1 graph;
注(2)：本文习题命题模仿对象第1题2004年真题text 4第1题，第2题模仿1994年真题text 3第1题，第3题模仿1996年真题text 3第3题，第4题模仿1997年真题text 3第2题，第5题2004年真题text 4第5题;
1. Why is America‘s pharmaceutical industry so unpopular?
[A] Because it， like tobacco and oil firms， does harm to people‘s health and environment.
[B] Because it fails to cure disease and make people live longer.
[C] Because the prices of its products are too high and its profit margin is too wide.
[D] Because it exploits its employees.
2. Alan Holmer is quoted to illustrate that __________.
[A] the comparison between tobacco and pharmaceutical industries might seem ridiculous， or even insulting
[B] the pharmaceutical industries agree that they are similar to tobacco industry
[C] tobacco products do more harm to people than pharmaceutical products
[D] pharmaceutical industries are currently facing lots of problems
3. According to the text， Mr. Parrish gives the following suggestions to drug firms except ______.
[A] To acknowledge the problems and try to do something to improve their images.
[B] Not to react to the public in one voice through the drug association.
[C] Not to care about the past.
[D] To try to spend time and energy to persuade the majority of the audience who are open to persuasion.
4. The word “mollify” (Line 1， Paragraph 4) might mean?
[A] placate.
[B] enrage.
[C] fight.
[D] relieve.
5. What does the author imply by saying “This is not the first time he has offered his
thoughts on dealing with implacable critics.“?
[A] Mr. Parrish has offered his advice to other on dealing with tough critics for several times.
[B] Mr. Parrish has dealt successfully with other critics himself.
[C] Mr. Parrish has given sound advice to drug firms.
[D] Mr. Parrish has been of help to others on critical moments.
答案：C A C A CSleep is a funny thing. We're taught that we should get seven or eight hours a night， but a lot of us get by just fine on less， and some of us actually sleep too much. A study out of the University of Buffalo last month reported that people who routinely sleep more than eight hours a day and are still tired are nearly three times as likely to die of stroke——probably as a result of an underlying disorder that keeps them from snoozing soundly.
Doctors have their own special sleep problems. Residents are famously sleep deprived. When I was training to become a neurosurgeon， it was not unusual to work 40 hours in a row without rest. Most of us took it in stride， confident we could still deliver the highest quality of medical care. Maybe we shouldn't have been so sure of ourselves. An article in the Journal of the American Medical Association points out that in the morning after 24 hours of sleeplessness， a person's motor performance is comparable to that of someone who is legally intoxicated. Curiously， surgeons who believe that operating under the influence is grounds for dismissal often don't think twice about operating without enough sleep.
“I could tell you horror stories，” says Jaya Agrawal， president of the American Medical Student Association， which runs a website where residents can post anonymous anecdotes. Some are terrifying. “I was operating after being up for over 36 hours，” one writes. “I literally fell asleep standing up and nearly face planted into the wound.”
“Practically every surgical resident I know has fallen asleep at the wheel driving home from work，” writes another. “I know of three who have hit parked cars. Another hit a 'Jersey barrier' on the New Jersey Turnpike， going 65 m.p.h.” “Your own patients have become the enemy，” writes a third， because they are “the one thing that stands between you and a few hours of sleep.”
Agrawal's organization is supporting the Patient and Physician Safety and Protection Act of 2001， introduced last November by Representative John Conyers Jr. of Michigan. Its key provisions， modeled on New York State's regulations， include an 80-hour workweek and a 24-hour work-shift limit.Most doctors， however， resist such interference. Dr. Charles Binkley， a senior surgery resident at the University of Michigan， agrees that something needs to be done but believes “doctors should be bound by their conscience， not by the government.”
The U.S. controls the hours of pilots and truck drivers. But until such a system is in place for doctors， patients are on their own. If you're worried about the people treating you or a loved one， you should feel free to ask how many hours of sleep they have had and if more-rested staffers are available. Doctors， for their part， have to give up their pose of infallibility and get the rest they need.
注(1)：本文选自Time;3/11/2002， p73， 3/4p， 1c;
注(2)：本文习题命题模仿对象：第1、2题分别模仿1999年真题text4的第1题和text2的第2题;第3题模仿1998年真题text3的第2题;第4、5题分别模仿2004年真题text2的第3题和text3的第5题;
1. We can learn from the first paragraph that ____________.
[A] people who sleep less than 8 hours a day are more prone to illness
[B] poor sleep quality may be a sign of physical disorder
[C] stroke is often associated with sleep
[D] too much sleep can be as harmful as lack of sleep
2. Speaking of the sleep problems doctors face， the author implies that ________________.
[A] doctors often need little sleep to keep them energetic
[B] doctors‘ sleep is deprived by residents
[C] doctors tend to neglect their own sleep problems
[D] sleep-deprived doctors are intoxicated
3. Paragraph 3 and 4 are written to ____________.
[A] entertain the audience with some anecdotes
[B] discuss the cause of doctors‘ sleep problems
[C] show the hostility doctors harbor against their patients
[D] exemplify the danger doctors face caused by lack of sleep
4. By “doctors should be bound by their conscience， not by the government” (line 6， paragraph 5)， Dr. Charles Binkley means that ____________.
[A] doctors should not abide by government‘s regulations
[B] the government is interfering too much
[C] the regulations about workweek and work shift are too specific
[D] law can not force a doctor to sleep while his conscience can
5. To which of the following is the author likely to agree?
[A] Patients should control the hours of their doctors.
[B] Pilots and truck drivers work in safer environments than that of doctors‘。
[C] Patients are facing more risks if their doctors are not adequately-rested.
[D] People concerned have the right to remove their doctors from their positions.
答案：B C D B CWatching a child struggle to breathe during an asthma attack is frightening for any parent. So it is only natural that most moms and dads will try just about anything——including spending a lot of money——to keep an attack at bay. Trouble is， more than half of parents are trying strategies that simply don't work and wasting hundreds of dollars in the process， according to a study published last week in the Journal of Allergy and Clinical Immunology.
The report， based on interviews with the parents of 896 asthmatic children in 10 different cities， contained some good news. Eighty percent of parents had a handle on at least one of the triggers that worsened their children's asthma. After that， however， many parents seemed to go astray， taking precautions that weren't helpful “and made little sense，” according to Dr. Michael Cabana， a pediatrician at the University of Michigan's C.S. Mott Children's Hospital， who led the study.
One of the most common mistakes was to buy a mattress cover to protect against dust mites for a child whose asthma was exacerbated instead by plant pollen. Many of those parents then neglected to do what would have helped a lot more： shut the windows to keep pollen out. Another was using a humidifier for a child who was allergic to dust mites; a humidifier tends to be a place where dust mites like to breed. With those allergies， a dehumidifier works better.
Worst of all was the number of smokers with asthmatic children who didn't even try to quit or at least limit themselves to smoking outdoors rather than just moving to another room or the garage. Second-hand smoke has been proved， over and over again， to be a major trigger of asthma attacks. Many smoking parents purchased expensive air filters that have what Cabana called “questionable utility.”
Part of the problem， Dr. Cabana and his colleagues believe， is that parents are bombarded by television ads that encourage them to buy products such as air and carpet fresheners， ionizers and other remedies that are often expensive but medically unnecessary. And doctors may not always take the time， or have the time， to explain to parents what will and won't work in their child's particular case. For example， allergies are usually a problem for older children with asthma， while kids 5 and younger more frequently have trouble with viral respiratory infections. So make sure you understand what's really triggering your child's asthma. And remember， the best solutions are not always the most expensive ones.
注(1)：本文选自Time，8/30/2004，p67;
注(2)：本文习题命题模仿对象2004年真题Text 1
1. What does the study by Dr. Michael Cabana indicate?
[A]Parents are eager to cure of their children‘s disease.
[B]Many parents are wasting money for their children‘s frightening disease.
[C] Many parents fail to find the effective way for their children‘s disease.
[D]Parents feel worried about their children‘s disease.
2. Which of the following is not the trigger of asthma attacks?
[A]Humidifier.
[B]Second-hand smoke.
[C]Plant pollen.
[D]Dust mites.
3. The expression “to keep an attack at bay” (Line 3， Paragraph 1) most probably means ________.
[A]to ease the attack
[B]to lessen the attack
[C]to continue the attack
[D]to prevent the attack
4. Why are the parents in such a dilemma?
[A]The doctors are not responsible enough.
[B]Parents are influenced much by ads.
[C]Parents are ignorant of the disease.
[D]The quality of medical products is not good.
5. Which of the following is true according to the text?
[A]Parents shouldn‘t spend too much money on the children.
[B]The expensive products are not always good.
[C]To know the real trigger of the disease is very important.
[D]Parents often make mistakes.
答案：CADBCIF YOU'RE CONFUSED BY ALL the news about the health effects of eating fish， you're not alone. On one hand， the omega-3 fatty acids in fish are known to reduce the risk of heart disease， as the American Heart Association reminded us two weeks ago when it restated its recommendation that everybody eat at least two fish servings a week. On the other hand， fish that feed in contaminated waterways contain high levels of mercury， which can lead to cognitive problems in developing brains. That's why pregnant women and nursing mothers are advised to limit their consumption.
As if that weren't confusing enough， two new studies published last week in the New England Journal of Medicine investigated the possible effects of mercury on the heart， and they seem to have reached contradictory conclusions. One found no clear link between mercury levels and heart disease; the other found that men with high levels of mercury in their toenails were more likely to suffer a heart attack than those with low levels. What are we to make of this? The first thing to remember is that this is how science proceeds， by fits and starts and seemingly contradictory results that get resolved only by further study. The second is that not all fish are created equal.
Compared with all the other things you might eat， fish are an excellent source of protein. They tend to eat algae as part of their natural life cycle， converting it into omega-3 fatty acids that can improve your cholesterol profile. But it's also true that our waterways have become increasingly contaminated with all sorts of pollutants， including mercury， and that these pollutants tend to accumulate at different levels in different species. The fish most at risk are predators high in the pelagic food chain， such as swordfish and sharks (see chart)。
It was to test the effects of mercury on the heart that the two new studies compared the mercury levels in clippings from toenails， where heavy metals tend to be deposited. In one study， researchers led by Dr. Eliseo Guallar at Johns Hopkins found that European and Israeli men with the highest mercury levels were nearly 2.2 times as likely to have a heart attack as those with the lowest levels. The other study， led by Dr. Walter Willett at the Harvard School of Public Health， looked at a selection of American men and found no connection between mercury exposure and risk of heart disease， although Willett told me a “weak association” cannot be ruled out.
For most of us， eating two servings of fish a week should not pose any problems. Guallar， who hails from coastal Spain， continues to flavor his paella with salmon， which has negligible mercury levels. Willett eats swordfish only about twice a month——because of its expense， not any fear of mercury. Fish-oil supplements are high in omega3 fatty acids and probably don't contain as much mercury as whole fish. But they don't taste nearly as good.
注(1)：本文选自Time; 12/9/2002， p99;
注(2)：本文习题命题模仿对象2005真题Text 1;
1. In the opening paragraph， the author introduces his topic by
[A]making a comparison
[B]justifying an assumption
[C]posing a contrast
[D]explaining a phenomenon
2. The phrase “by fits and starts”(Line 6， Paragraph 2) most probably means _______.
[A]something happens smoothly
[B]something keeps starting and then stopping again
[C]something deserves a lot of effort
[D]something is troublesome
3. Clippings from toenails were chosen for the research most probably because _______.
[A]they are more likely to contain mercury
[B]they influence a person‘s heart
[C]they can be easily obtained
[D]they are connected with the heart
4. The views of Dr. Eliseo Guallar and Dr. Walter Willett are ______.
[A]identical
[B]similar
[C]opposite
[D]complementary
5. What can we infer from the last paragraph?
[A]Fish is no threat to Man.
[B]Do not be frightened by some fish.
[C]Eat Fish-oil supplements instead of fish.
[D]Taste is more important than the safety of the food.
答案：CBACBA widely heralded but still experimental cancer-fighting compound may be used someday to prevent two other major killers of Americans： heart disease and stroke. That was the implication of a remarkable report published last week in the journal Circulation by a team of researchers from Dr. Judah Folkman's laboratory at the Children's Hospital in Boston.
The versatile compound is endostatin， a human protein that inhibits angiogenesis， the growth of new blood vessels in the body. In tests reported in 1997 by Folkman， a prominent cancer researcher who pioneered the study of angiogenesis， the drug had reduced and even eradicated tumors in laboratory mice. How? By stunting the growth of capillaries necessary for nourishing the burgeoning mouse tumors.
When news of Folkman's achievement became widely known last year， it led to wildly exaggerated predictions of imminent cancer cures. When other scientists were initially unable to duplicate those results， questions arose about the validity of Folkman's research. Then in February scientists at the National Cancer Institute， with guidance from Folkman， finally matched his results. Reassured， the N.C.I. gave the go-ahead for clinical trials of endostatin later this year on patients with advanced tumors.
How can a drug that is app
